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Synthetic Studies on Selectin Ligands/Inhibitors: Synthesis and Inhibitory Activity of 2-O-Fucosyl Sulfatides Containing 2-Branched Fatty Alkyl Residues in Place of Ceramide

 

作者: Takao Ikami,   Takuji Kakigami,   Kunihisa Baba,   Hitoshi Hamajima,   Takahito Jomori,   Toshinao Usui,   Yasuo Suzuki,   Harunari Tanaka,   Hideharu Ishida,   Akira Hasegawa,   Makoto Kiso,  

 

期刊: Journal of Carbohydrate Chemistry  （Taylor Available online 1998）
卷期: Volume 17, issue 3  

页码: 453-470

 

ISSN:0732-8303

 

年代: 1998

 

DOI:10.1080/07328309808002905

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

To investigate the biological selectin-ligand interactions, four sulfated 2-O-α-L-fucopyranosyl β-D-galactopyranosides containing 2-branched fatty-alkyl residues in place of ceramide have been systematically synthesized. The target glycolipids were assayed for their ability to block the adhesion of HL-60 cells to immobilized P-, L- and E-selectin. Among them, 2-O-α-L-fucopyranosyl sulfatide, which is anchored with 2-(tetradecyl) hexadecyl residue showed significantly more potency of the blocking adhesion to P- and L-selectins.

 

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