Immunologic Effects of Cocaine and Related Alkaloids
作者:
DelafuenteJeffrey C.,
DevaneC. Lindsay,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1991)
卷期:
Volume 13,
issue 1-2
页码: 11-23
ISSN:0892-3973
年代: 1991
DOI:10.3109/08923979109019688
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractBecause of the national epidemic of cocaine abuse and the increasing prevalence of infectious diseases among drug abusers, we investigated the effects of cocaine and cocaine metabolites on human cellular immune functions. Mononuclear cells (MNC) were isolated from blood of healthy adult volunteers. MNC were stimulated in vitro with mitogens with and without various concentrations of cocaine. Because of cocaine's poor stability in vitro, we found it necessary to replenish cocaine daily to MNC cultures. Under these conditions, cocaine, in a dose response fashion, significantly inhibited MNC proliferation: Metabolites of cocaine did not alter MNC proliferative responses significantly from control cultures. Polymorphonuclear leukocyte chemotaxis was also significantly impaired by cocaine. Our data demonstrate that cocaine is immunosuppressive and that it acts on human MNC during early stages of cellular activation. These data further suggest that illicit cocaine use may compromise the integrity of the immune system.
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