11q deletions in human colorectal carcinomas: Cytogenetics and restriction fragment length polymorphism analysis
作者:
Peter L. Keldysh,
Tommaso A. Dragani,
Elena W. Fleischman,
Liliya N. Konstantinova,
Alexander G. Perevoschikov,
Marco A. Pierotti,
Giuseppe Della Porta,
Boris P. Kopnin,
期刊:
Genes, Chromosomes and Cancer
(WILEY Available online 1993)
卷期:
Volume 6,
issue 1
页码: 45-50
ISSN:1045-2257
年代: 1993
DOI:10.1002/gcc.2870060109
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractDeletions and/or allelic losses of a portion of the long arm of chromosome 11 were discovered by cytogenetic and restriction fragment length polymorphism analyses in 23 of 39 (59%) informative cases of colorectal carcinoma. By comparing the patterns of loss of heterozygosity and chromosome rearrangements in different patients, we could map a common target region to 11q22‐23. This region may contain a tumor suppressor gene, the inactivation of which may be involved in the development of tumors of the large intestine. The subgroup of malignancies with 11q alterations seemed to be enriched by tumors that were located in the rectum, that were Dukes' stage A, and that were well differentiated and mucin producing.© 1993 Wiley‐
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