Suppressed Serum and Urine Levels of Indoxyl Sulfate by Oral Sorbent in Experimental Uremic Rats
作者:
Toshimitsu Niwa,
Takashi Miyazaki,
Naosumi Hashimoto,
Hideo Hayashi,
Michihito Ise,
Yasuo Uehara,
Kenji Maeda,
期刊:
American Journal of Nephrology
(Karger Available online 1992)
卷期:
Volume 12,
issue 4
页码: 201-206
ISSN:0250-8095
年代: 1992
DOI:10.1159/000168447
出版商: S. Karger AG
关键词: Oral sorbent;AST-120;Indoxyl sulfate;Hippuric acid;Uremia
数据来源: Karger
摘要:
In uremic patients, the serum concentration of indoxyl sulfate is markedly increased. To determine if oral sorbent (AST-120) suppresses the endogenous synthesis of indoxyl sulfate, it was administered to experimental uremic rats, and the serum concentration and urinary excretion of indoxyl sulfate were quantified by high-performance liquid chromatography. Oral sorbent decreased both the serum concentration and urinary excretion of indoxyl sulfate, suggesting that there was suppression of the endogenous synthesis of indoxyl sulfate by the oral sorbent. Oral sorbent did not decrease the serum concentration and urinary excretion of hippuric acid, but it did alleviate the deterioration of renal function in the experimental uremic rats.
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