Human B Cell Lymphomas:In VitroandIn VivoStudies on Growth Factors and Cell Growth
作者:
FordRichard J.,
TamayoArchie,
LiDai Jun,
CabanillasFernando,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 10,
issue sup1
页码: 51-56
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309149112
出版商: Taylor&Francis
关键词: Non-Hodgkin's lymphoma;B lymphocyte;B cell growth factors (BCGFs);cytokines;autocrine cell growth
数据来源: Taylor
摘要:
The B cell non-Hodgkin's lymphomas (NHL-B) are a common, but heterogeneous group of human lymphoid neoplasms, consisting of monoclonal populations of neoplastic B lymphocytes demonstrating non-random chromosomal abnormalities, often associated with proto-oncogene translocations. Clinically and pathologically, these lymphomas are classified as low, intermediate, or high grade, according to the clinical aggressiveness of the NHL-B subtype. The clinical behavior can also be correlated with biological function regarding proliferative capabilities of the tumor cells. Our studies have shown that the low grade B cell lymphomas have low constitutive proliferative capacity in vitro and do not respond to cytokine growth factors (CGF), while the high grade NHL-B respond to the B cell growth factor (BCGF) family of CGFs. The high grade NHL-B also secrete BCGFs both in vitro and in vivo, as autocrine growth factors that may provide a target for new therapeutic approaches to therapy.
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