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Human B Cell Lymphomas:In VitroandIn VivoStudies on Growth Factors and Cell Growth

 

作者: FordRichard J.,   TamayoArchie,   LiDai Jun,   CabanillasFernando,  

 

期刊: Leukemia&Lymphoma  (Taylor Available online 1993)
卷期: Volume 10, issue sup1  

页码: 51-56

 

ISSN:1042-8194

 

年代: 1993

 

DOI:10.3109/10428199309149112

 

出版商: Taylor&Francis

 

关键词: Non-Hodgkin's lymphoma;B lymphocyte;B cell growth factors (BCGFs);cytokines;autocrine cell growth

 

数据来源: Taylor

 

摘要:

The B cell non-Hodgkin's lymphomas (NHL-B) are a common, but heterogeneous group of human lymphoid neoplasms, consisting of monoclonal populations of neoplastic B lymphocytes demonstrating non-random chromosomal abnormalities, often associated with proto-oncogene translocations. Clinically and pathologically, these lymphomas are classified as low, intermediate, or high grade, according to the clinical aggressiveness of the NHL-B subtype. The clinical behavior can also be correlated with biological function regarding proliferative capabilities of the tumor cells. Our studies have shown that the low grade B cell lymphomas have low constitutive proliferative capacity in vitro and do not respond to cytokine growth factors (CGF), while the high grade NHL-B respond to the B cell growth factor (BCGF) family of CGFs. The high grade NHL-B also secrete BCGFs both in vitro and in vivo, as autocrine growth factors that may provide a target for new therapeutic approaches to therapy.

 

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