Fibroblast Growth Factor: Effects on Osteogenesis and Chondrogenesis in the Chick Embryo
作者:
S.R. Frenkel,
M.S. Herskovits,
I.J. Singh,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 145,
issue 3
页码: 265-268
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147375
出版商: S. Karger AG
关键词: Fibroblast growth factor;Osteogenesis;Chondrogenesis;Autoradiography;Η-proline
数据来源: Karger
摘要:
In vivo effects of fibroblast growth factor (FGF) on osteogenesis were evaluated in the chick embryo. Autoradiographic studies of Η-proline labeling over bone matrix indicated that 24 h after treatment on day 11, FGF stimulated osteogenic cell proliferation, while inhibiting the production of bone matrix collagen. However, 4 days after multiple doses of FGF, the large pool of newly formed osteogenic and chondrogenic cells expressed their function with the increased formation of matrix. The data provide in vivo evidence of the effects of exogenous FGF on osteogenesis and also point to a possible role for FGF both in embryonic osteogenesis and in fracture repair
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