Production of Hepatocyte Growth Factor Is Increased in Chronic Renal Failure
作者:
Kazunobu Sugimura,
Chyi-Chia R. Lee,
Taku Kim,
Takeshi Goto,
Shinji Kasai,
Kouji Harimoto,
Seiji Yamagami,
Taketoshi Kishimoto,
期刊:
Nephron
(Karger Available online 1997)
卷期:
Volume 75,
issue 1
页码: 7-12
ISSN:1660-8151
年代: 1997
DOI:10.1159/000189492
出版商: S. Karger AG
关键词: Hepatocyte growth factor;Production;Processing;Chronic renal failure
数据来源: Karger
摘要:
Hepatocyte growth factor (HGF) facilitates recovery from tissue injuries. We previously reported that serum HGF levels were elevated in chronic renal failure (CRF) patients. In the present study Western blot analysis of CRF patients’ sera showed the majority of their serum HGF was a single-chain precursor molecule. In CRF rats developed by 5/6 nephrectomy or high adenine diet, both HGF mRNA expression levels and tissue HGF concentrations were increased in liver and spleen. The results suggest that HGF production increases in CRF, which may be a response to chronic progressive renal injuries in an endocrine manne
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