The initial development of the human brain
作者:
Ronan O'Rahilly,
Ernest Gardner,
期刊:
Cells Tissues Organs
(Karger Available online 1979)
卷期:
Volume 104,
issue 2
页码: 123-133
ISSN:1422-6405
年代: 1979
DOI:10.1159/000145061
出版商: S. Karger AG
关键词: Human neuroembryology;Embryonic brain;Neuropores;Neuromeres;Subdivisions of brain
数据来源: Karger
摘要:
An account of the early development of the human brain has been prepared from the data available for the Carnegie Collection, as well as from published information from other sources. Although the site of the neural plate can be discerned at stage 7, the first visible indication of the nervous system is the neural groove in certain embryos of stage 8, in which the embryonic disc measures more than 1 mm and the notochordal process at least 0.3 mm. The progressive fusion of the neural folds during stage 10, and the closure of the rostral and caudal neuropores at stages 11 and 12, respectively, are detailed with further precision than hitherto. It is emphasized that the major subdivisions of the human brain do not begin as vesicles, but as enlargements of the open neural folds at stage 9. The relationships of the neuromeres to the otic region, the somites, and the neural crest are clarified and illustrated. The early appearance of the telencephalon medium (before cerebral vesicles have formed) is stressed, and the terminological implications for the subdivisions of the brain are discussed.
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