Interleukin-1: Biological Effects in Human Hematopoiesis
作者:
CrownJohn,
JakubowskiAnn,
GabriloveJanice,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 9,
issue 6
页码: 433-440
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309145750
出版商: Taylor&Francis
关键词: Interleukin 1;biological effects;hematopoiesis
数据来源: Taylor
摘要:
Interleukin-1 (IL-1) produces many direct and indirect effects in hematopoiesis. IL-1 stimulates hematopoietic progenitors, and enhances production of other cytokines. Experimental data suggest a role in ameliorating the myelosuppression that occurs following cytotoxic chemotherapy. Recombinant human interleukin-1 has now entered clinical trial. We conducted a phase I trial of IL-1βalone, and following a myelosuppressive dose of 5-fluorouracil in patients with cancer. A prominent neutrophilia was noted within several hours, with a later, more sustained thrombocytosis. Hypotension was dose-limiting. We observed fewer days of neutropenia following 5-FU plus IL-1 compared to IL-1 alone, but the difference did not reach statistical significance. Early results from other investigators suggest a possible protective effect from chemotherapy-induced myelosuppression. Preclinical data suggest that combinations of IL-1 and lineage specific growth factors may produce synergistic hematologic effects.
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