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A new Case of Hb Little Rock [β143(H21)His→Gln], a high affinity variant. Study during pregnancy

 

作者: FrancinaA.,   LacombeC.,   BakloutiF.,   DorléacE.,   DelaunayJ.,   SouilletG.,   RudigozR. C.,   ArousN.,   RosaJ.,   GalacterosF.,  

 

期刊: Hemoglobin  （Taylor Available online 1987）
卷期: Volume 11, issue 2  

页码: 113-122

 

ISSN:0363-0269

 

年代: 1987

 

DOI:10.3109/03630268709005784

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

A new case of Hb Little Rock [βl43(H21)His→G1n] is described. This high affinity variant (P50= 15 mm Hg in whole cells) has a nearly normal cooperativity. The abnormalβchain is readily detectable using urea-Triton X-100 electrophoresis. The alteredβT-14 peptide was separated by high performance liquid chromatography. The proposita was followed during a pregnancy. Oxygen unloading was reduced, but normal oxygen loading was maintained in the fetus. There were neither placental abnormalities, nor intrauterine growth retardation.

 

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