EPIDEMIOLOGIC ASSESSMENT OF MEASURES USED TO INDICATE LOW-LEVEL EXPOSURE TO MERCURY VAPOR (Hg°)
作者:
MargaretE. Cianciola,
Diana Echeverria,
MichaelD. Martin,
H. Vasken Aposian,
JamesS. Woods,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1997)
卷期:
Volume 52,
issue 1
页码: 19-33
ISSN:0098-4108
年代: 1997
DOI:10.1080/00984109708984050
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Mercury (Hg) concentrations in individual spot urine samples collected over consecutive I'd periods were compared with Hg concentrations measured in combined 24-h urine samples from 69 practicing dental professionals with low exposure to Hg vapor (Hg°) in order to validate the use of spot urine samples as an indicator of Hg exposure. The level of Hg° in air as an exposure measure was also evaluated by comparing air concentrations of Hg° in dental offices with both spot and 24-h urine Hg° levels. The results showed: (1) There was little diurnal variation (∼9%) in urinary Hg values; (2) a strong correlation (R2=.85) exists between the Hg concentration in the first morning void and that in a complete 24-h urine sample; (3) adjustment of urinary Hg levels for creatinine concentrations did not improve this correlation; (4) there was no added value in the speciation of total urinary Hg into the inorganic Hg fraction; and (5) concentrations of Hg° in air did not significantly correlate with measures of Hg in urine at this low Hg° exposure level. We conclude from this study that first morning void urine samples may be used to derive reasonably valid
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