Pentoxifylline Does Not Prevent Haemodialysis Induced Neutropaenia or Hypoxaemia
作者:
B.L. Rayner,
M.D. Pascoe,
G. Thebus,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 60,
issue 3
页码: 363-365
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186780
出版商: S. Karger AG
关键词: Pentoxifylline;Haemodialysis;Neutropaenia;Hypoxaemia
数据来源: Karger
摘要:
The aim of the study was to determine if oral pentoxifylline prevented dialysis induced hypoxaemia and neutropaenia. Fifteen stable chronic haemodialysis patients were routinely dialysed using either a cuprophane or cellulose acetate membrane. Bloods for white blood count (WCC) and pO2 were taken at time 0, 20,80,140 and 200 min. The procedure was repeated in the same patients 2 h after the ingestion of 400 mg of pentoxifylline. There was a highly significant drop in WCC at time 20 min and pO2 over the dialysis period, which was not prevented by pentoxifylline. Pentoxifylline levels taken at time 0 in 11 patients were in the therapeutic range and it is concluded that pentoxifylline does not prevent dialysis induced neutropaenia or hypoxaemia.
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