Haloperidol Inhibits Neuronal Nitric Oxide Synthase Activity by Preventing Electron Transfer
作者:
Kazuhiko Iwahashi,
Hirohito Yoneyama,
Taira Ohnishi,
Kazuhiko Nakamura,
Ryosuke Miyatake,
Hiroshi Suwaki,
Kiyoshi Hosokawa,
Yoshiyuki Ichikawa,
期刊:
Neuropsychobiology
(Karger Available online 1996)
卷期:
Volume 33,
issue 2
页码: 76-79
ISSN:0302-282X
年代: 1996
DOI:10.1159/000119253
出版商: S. Karger AG
关键词: NOS;P45O;Haloperidol;Inhibition;NADPH;Oxyhemoglobin;L-Arginine
数据来源: Karger
摘要:
The effect of a neuroleptic, haloperidol (HP), on nitric oxide formation catalyzed by neuronal nitric oxide synthase (n-NOS) in the porcine brain was investigated. HP inhibited n-NOS activity noncompetitively versus L-arginine as a substrate, decreasing the maximal velocity (Ki value for HP = 31 µM). HP also inhibited the CaM-dependent NADPH consumption by n-NOS (IC50 = 221 µM). These data demonstrate the possibility that HP may mediate some neuronal functions through inhibiting NO release by preventing either the electron transfer through n-NOS or the formation of the activated reduced species of oxygen necessary for the formation of citrulline. And an interaction of HP with CaM may possibly affect the consumption of NADPH and n-NOS enzyme activit
点击下载:
PDF
(655KB)
返 回