Effects of Selegiline Dosing on Motor Fluctuations in Parkinson's Disease
作者:
Jean Hubble,
William Koller,
Cheryl Waters,
期刊:
Clinical Neuropharmacology
(OVID Available online 1993)
卷期:
Volume 16,
issue 1
页码: 83-87
ISSN:0362-5664
年代: 1993
出版商: OVID
关键词: Selegiline;Deprenyl;Parkinson disease;Motor fluctuation
数据来源: OVID
摘要:
SummaryTo examine selegiline's dosing effects, we studied 16 Parkinson disease patients with motor fluctuations in a double-blind, crossover trial of selegiline at 0, 5, and 10 mg daily. Patients' motor diaries, disability scores, and walking speed were marginally improved, with no advantage of 10 mg over 5 mg found. We conclude that in patients with motor fluctuations, selegiline provides modest symptomatic effects, with daily dosing of 5 mg being indistinguishable from 10 mg.
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