Hb Tacoma [β30(B12) Arg→Ser], A Slightly Unstable Hemoglobin Variant Found in Japan
作者:
HaranoK.,
HaranoT.,
UedaS.,
MoriH.,
ShibataS.,
TakedaI.,
TsunematsuT.,
期刊:
Hemoglobin
(Taylor Available online 1985)
卷期:
Volume 9,
issue 6
页码: 635-639
ISSN:0363-0269
年代: 1985
DOI:10.3109/03630268508997047
出版商: Taylor&Francis
数据来源: Taylor
摘要:
In August 1983, during the course of a hemoglobinopathy survey in Shimane Prefecture, we found a slightly fast-moving abnormal hemoglobin by isoelectric focusing (1). Structural analysis of this hemoglobin demonstrated it to be identical to Hb Tacoma, possessing an amino acid substitution of Arg→Ser at the position ofβ30. Hb Tacoma is known as a slightly unstable hemoglobin variant detected at first in America (2) and then in the Soviet Union (3), Finland (4) and again in America (5). The fourth case in America was a double heterozygote of Hb S and Hb Tacoma. Thus this is the fifth case in the world and the first case in Japan.
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