Metabolic responses of rats to chronic theophylline ingestion
作者:
RichardB. Tobin,
Beverly Friend,
CarolynD. Berdanier,
MyronA. Mehlman,
Viola DeVore,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1976)
卷期:
Volume 2,
issue 2
页码: 361-369
ISSN:0098-4108
年代: 1976
DOI:10.1080/15287397609529439
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Studies of the metabolic responses of rats to 0.2% dietary theophylline were conducted. Young male rats were fed theophylline‐containing diets or control diets for 8 wk and killed after 22 hr without food. Levels of serum lipids, glucose, and ketones were determined as were hepatic glycogen, lipid, calcium, magnesium, and zinc levels. Epididymal fat pad lipid content, as well as kidney cation levels and hepatic mitochondrial respiration, was also determined. Chronic theophylline feeding lowered blood glucose levels, serum triglyceride levels, hepatic lipid and calcium levels, and the state III respiration with succinate as the substrate. Kidney calcium and magnesium levels were elevated in theophylline‐fed rats as were the serum cholesterol levels. The relationship of these metabolic responses to theophylline feeding is discussed as a function of the theophylline effect on tissue cation levels.
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