Developmental Regulation of Cytokine Expression in the Mouse Brain
作者:
BurnsTed M.,
CloughJohn A.,
KleinRobert M.,
WoodGary W.,
BermanNancy E. J.,
期刊:
Growth Factors
(Taylor Available online 1993)
卷期:
Volume 9,
issue 4
页码: 253-258
ISSN:0897-7194
年代: 1993
DOI:10.3109/08977199308991585
出版商: Taylor&Francis
关键词: cytokines;brain development;transforming growth factor-β;tumor necrosis factor-α;colony-stimulating factor;interleukin-6
数据来源: Taylor
摘要:
Expression of four cytokine genes, transforming growth factor (TGF)β2, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and macrophage colony-stimulating factor (CSF-1 also known as M-CSF) was examined to determine whether these genes are developmentally regulated in the brain. Northern blots were performed on RNA isolated from the mouse brain from embryonic day 15 (E15) through postnatal day 9. TGFβ2, gene expression was relatively high in the earliest embryos studied and decreased after E16-E17, and the three transcripts were developmentally regulated. TNF-αand IL-6 were detected in total RNA on all days studied. CSF-1 was detected only in polyadenylated RNA. The data suggest that expression of these cytokines is related to specific developmental events that share cellular functions with regenerative or inflammatory processes.
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