&NA;A prospective and retrospective evaluation of 75 patients with hand wounds contaminated by human saliva (35) or animal saliva (40) demonstrates that a program of outpatient management can be sufficient for optimal care in many patients. This series challenges the proposition that hospitalization, radiographs, and surgical debridement are necessary for most such wounds. Sixty‐seven per cent did not have surgical intervention and no complications resulted. Ninety‐two per cent received antibiotics. Radiographs were obtained only when bony injury or entry into a joint was suspected. Delay in seeking treatment until obvious signs of infection or pain are present is common. Literature review details the anatomic factors important in the natural history and control of these infections, and the changes with respect to modes of treatment for these potentially dangerous wounds. The injury is caused by bites with the hand extended or, in fight‐bite wounds, with the metacarpal‐phalangeal and interphalangeal joints flexed, allowing deeper penetration and then sealing of the wound when the first is opened.StaphylococcusandStreptococcusare the organisms most frequently found in human bites, and in animal bites;Pasteurella multocidashould be considered in dog and cat bites.