Hyperimmunoglobulinemia D following Cancer Chemotherapy
作者:
Eiichi Azuma,
Shin-ichi Masuda,
Motoi Hanada,
Yan-Wen Zhou,
Shao-Li Zhang,
Takeo Shibata,
Yoshihiro Komada,
Minoru Sakurai,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 5
页码: 387-391
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226965
出版商: S. Karger AG
关键词: Hyperimmunoglobulinemia D;Cancer;Chemotherapy
数据来源: Karger
摘要:
Five classes of serum immunoglobulin levels were investigated in 107 children with malignant or benign tumors. Hyperimmunoglobulinemia D (hyper-IgD) was observed in 31 of 82 children who were in complete remission off chemotherapy with a median follow-up of 4.5 years after cessation of chemotherapy. On the other hand, hyper-IgD was not found among 12 children with malignant or benign tumors treated without chemotherapy and a low incidence of hyper-IgD was observed during chemotherapy (1 of 13 cases). The result indicates that hyper-IgD is not uncommon in children off chemotherapy, suggesting that dysregula-tion of IgD synthesis persists long after cessation of antineoplastic drugs.
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