The Somatotropin-Somatomedin Axis in Adult Patients with Turner Syndrome: Measurement of Stimulated GH, GH-BP, IGF-I, IGF-II and IGFBP-3 in 25 Patients
作者:
R.W. Holl,
D. Kunze,
W.F. Blum,
R. Benz,
H. Elzrodt,
E. Heinze,
期刊:
Hormone Research in Paediatrics
(Karger Available online 1993)
卷期:
Volume 39,
issue 1-2
页码: 30-35
ISSN:1663-2818
年代: 1993
DOI:10.1159/000182691
出版商: S. Karger AG
关键词: Growth hormone;Insulin-like growth factor;Binding protein;Turner syndrome;Short stature;Body mass index;Estradiol
数据来源: Karger
摘要:
So far, few studies have addressed the regulation of GH and GH-dependent growth factors in adult patients with Turner syndrome. We therefore studied a group of 25 genetically proven patients with Turner syndrome (age 20-50 years) and 10 control women (25-48 years). Turner patients were significantly shorter (148.7 ± 1.1 cm vs. 169.1 ± 2.3 cm; mean ± SE; p < 0.0001) and more overweight [body mass index (BMI)] 25.6 ± 1.3 vs. 21.4 ± 0.6 in controls; p < 0.01). No significant differences were present when the integrated GH response to stimulation with arginine and the serum levels of GH-binding protein (GH-BP), IGF-I, IGF-II and binding protein 3 for IGFs (IGFBP-3) were compared between the two groups. However, more detailed analysis revealed significant abnormalities of the somatotropic axis in Turner patients. Pituitary GH secretion was negatively and serum GH-BP positively related to the degree of overweight in normal patients. In Turner patients, no such relationship was present, while IGF-II significantly increased with BMI. IGFBP-3 was positively related to adult height in normal women but not in Turner patients. While serum testosterone values did not affect any of the somatotropic parameters measured, there was a previously unreported, inverse relation between serum estradiol and GH-BP in controls but not in Turner patients. While adult patients with Turner syndrome do not display endocrine features of GH insufficiency, a detailed analysis reveals several abnormalities of the interrelation between anthropometric parameters, sex steroids and the pituitary-somatomedin
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