Aztreonam in the Treatment of Bacterial Meningitis
作者:
P.A. Ayroza-Galvão,
T.M. Milstein-Kuschnaroff,
I.M. Mimica,
S. Maassen,
S.P. Barbosa, Jr.,
N.J.F. Cavalcante,
R. Lorenco,
L.M.J. Mimica,
M.D.V. Martino,
期刊:
Chemotherapy
(Karger Available online 1989)
卷期:
Volume 35,
issue 1
页码: 39-44
ISSN:0009-3157
年代: 1989
DOI:10.1159/000238719
出版商: S. Karger AG
关键词: Bacterial meningitis;Aztreonam;Monobactam
数据来源: Karger
摘要:
The monobactam aztreonam was used to treat 22 young patients with meningitis caused by gram-negative bacilli. Haemophilus influenzae was isolated from the CSF of 21 patients and Salmonellaheidelberg from the CSF of 1. Dosages ranged from 100 to 200 mg/kg/day in 4 doses at 6-hour intervals. Minimal inhibitory concentrations were determined by the broth dilution method for all isolated strains, and values ranged from 0.05 to 2.0 μg/ml. Blood and CSF drug levels were determined by a microbiologic plate diffusion method, and mean values for CSF and blood were 1.4 and 14.9 μg/ml, respectively. The outcome was good in 21 patients; 1 patient died. Complications were mild: subdural effusion occurred in 6 cases and was managed clinically; asymptomatic hydrocephalus was seen in 4; seizure during the acute phase occurred in 6 cases; hypo-acusis was noted in 2, and motor impairment was detected at the follow-up in 1 case. Aztreonam achieved good blood and CSF penetration and performed well in the treatment of 20 cases of H. influenzae meningitis and in the one case of S. heidelberg meningiti
点击下载:
PDF
(1696KB)
返 回