Elimination of Stabilised Hyaluronan from the Knee Joint in Healthy Men
作者:
Ulla Lindqvist,
Vladimir Tolmachev,
Kalevi Kairemo,
Gunnar Åström,
Eva Jonsson,
Hans Lundqvist,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 2002)
卷期:
Volume 41,
issue 8
页码: 603-613
ISSN:0312-5963
年代: 2002
出版商: ADIS
关键词: Antirheumatics, pharmacokinetics;Hyaluronan, pharmacokinetics
数据来源: ADIS
摘要:
ObjectiveTo investigate the elimination of stabilised hyaluronan following intra-articular injection into the knee joint.DesignThis was a single-centre, single-dose study in healthy human volunteers.ParticipantsSix healthy men, aged 28 to 47 (mean 38) years, were enrolled in the study.MethodsSubjects received a single intra-articular injection (3ml; 20 mg/ml) of131I-labelled non-animal stabilised hyaluronic acid (NASHA). Radioactivity in the knee, blood, urine and over the liver was measured with gamma counters for 3 weeks post-injection; magnetic resonance and gamma camera imaging of the knee were also performed at 24 hours post-injection. Radioactivity uptake data were tested for conformity of fit to different mathematical models.ResultsElimination of131I-labelled NASHA from the knee was characterised by a fast initial phase and a slow late phase, and conformed to a three-exponential-function model with elimination half-lives of 1.5 hours, 1.5 days and 4 weeks. Radioactivity distribution within the knee joint was homogenous, and no local leakage was observed. Hepatic radioactivity uptake was low, but significantly above background levels, for the first 2 days post-injection, before declining to background levels. Visual imaging indicated an increase in intra-articular fluid volume at 24 hours post-injection.ConclusionsThe elimination kinetics of131I-labelled NASHA from the human knee joint were described by three distinct phases, with half-times of 1.5 hours, 1.5 days and 4 weeks. Most likely, the last value reflects the true half-life of NASHA following intra-articular injection since the labelling method used causes minimal modification of hyaluronan.@SUMMARY ORA =
点击下载:
PDF
(358KB)
返 回