Usefulness of the Two-Compartment Open Model in Pharmacokinetics
作者:
CarlM. Metzler,
期刊:
Journal of the American Statistical Association
(Taylor Available online 1971)
卷期:
Volume 66,
issue 333
页码: 49-53
ISSN:0162-1459
年代: 1971
DOI:10.1080/01621459.1971.10482216
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Compartment models are widely used in pharmaceutical research to quontitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed. This discussion shows that, in spite of the extreme simplification and obvious weaknesses of this model, it has properties that make it a useful tool in drug research when properly used.
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