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An Improved Time-Saving Synthesis for [11CMethyl] Iodide

 

作者: J. Steinbach,   G. J. Beyer,   K. Günther,  

 

期刊: Isotopenpraxis Isotopes in Environmental and Health Studies  （Taylor Available online 1989）
卷期: Volume 25, issue 11-12  

页码: 514-515

 

ISSN:0021-1915

 

年代: 1989

 

DOI:10.1080/10256018908624202

 

出版商: Taylor & Francis Group

 

关键词: Carbon 11;methyl iodide;positron computed tomography;precursor;radiopharmaceuticals;synthesis

 

数据来源: Taylor

 

摘要:

[11]CMethyliodide is a key to a large scale of11C-PET-radiopharmaceuticals. A method was devised for its efficient production in a yield between 85 and 90% within 7 minutes only. The use of tetrahydrofuran (THF) opens the possibility to absorb the starting [11C]CO2at room temperature. The methyl iodide generation from its precursor can be achieved in THF directly or in aqueous solution.

 

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