Heterogeneous palladium‐catalyzed exchange labelling of representative organic compounds with tritium gas
作者:
Philip G. Williams,
Chit Than,
Sadegh Rabbani,
Mervyn A. Long,
John L. Garnett,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1995)
卷期:
Volume 36,
issue 1
页码: 1-14
ISSN:0362-4803
年代: 1995
DOI:10.1002/jlcr.2580360102
出版商: John Wiley&Sons, Ltd.
关键词: Heterogeneous palladium;tritium gas;tritium NMR;radio‐glc
数据来源: WILEY
摘要:
AbstractA range of organic substrates was successfully exchanged with tritium gas using NaBH4‐reduced palladium oxide or chloride as catalyst. Exchange conditions involved a reaction temperature of 100 °C, a reaction time of 3 days, and products were analyzed by radio‐gas chromatography and3H NMR spectroscopy. Both aromatic and aliphatic compounds underwent exchange, 18 of the 22 substrates incorporated>35% of the available tritium, and most products showed high radiochemical purity.3H NMR analyses showed that both alkanes and the alkyl chains of alkylbenzenes were rapidly and evenly labelled. Some aromatic compounds showed general ring exchange while others showed high specificity. These results for bulk palladium catalyst are strikingly different from those obtained with bulk platinum and supported palladium catalysts. The results are discussed in terms of currently accepted mechanisms of heterogeneous metal catalyzed hydrogen isotope exchange react
点击下载:
PDF
(680KB)
返 回