Despite the importance of the recreational fishery for striped bassMorone saxatilisalong the eastern coast of the United States, little is known about the survival rates of caught and released striped bass. We predicted long-term (58-d) hooking mortality of striped bass after catch and release in saltwater using a logistic regression model. Experimental fishing was conducted on fish (27–57 cm) in a 2-ha saltwater impoundment in Salem, Massachusetts. Depth of hook penetration in the oral cavity, anatomical site of hooking, gear type (treble or single hooks), and angler experience were significantly related to mortality (P< 0.05). The logistic regression model was developed with backwards stepwise selection to predict probability of death from hooking. The final model included depth of hook penetration, gear type, and angler experience as predictor variables. Predicted mortality ranged from 3% under the most favorable conditions to 26% for the worst set of conditions. Predicted as well as observed mortality for the entire experimental group was 9% which is generally much lower than reported in striped bass hooking mortality studies conducted in freshwater. At the end of the experiment, condition factors were significantly lower for surviving hooked fish than for fish that had not been hooked.