Lidocaine Depresses Synaptic Activity in the Rat Hippocampal Slice
作者:
Avital Schurr,
Bruce Spears,
Kenneth Reid,
Catherine West,
Harvey Edmonds,
Benjamin Rigor,
期刊:
Anesthesiology
(OVID Available online 1986)
卷期:
Volume 64,
issue 4
页码: 501-503
ISSN:0003-3022
年代: 1986
出版商: OVID
关键词: Anesthetics, local: lidocaine;Brain: convulsions; hippocampus;Toxicity: lidocaine
数据来源: OVID
摘要:
The direct effect of the local anesthetic lidocaine was studied using the hippocampal slice preparation in order to assess the involvement of this structure in lidocaine-induced seizure activity. Changes in the evoked field potential amplitude and latency were used to measure the effect of the drug. A dose-dependent depression of the evoked field potentials was observed at lidocaine concentration of 10−4M and greater. No synchronized population bursting (seizures) was observed at any of the concentrations tested (10−6M to 10−3M). However, the hippocampal slice preparation is capable of producing seizure activity, as was demonstrated following application of penicillin G. The results suggest that the hippocampus is not the site of lidocaine-induced seizure activity.
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