Inflammatory Mediators and the Failing HeartPast, Present, and the Foreseeable Future
作者:
Douglas Mann,
期刊:
Circulation Research: Journal of the American Heart Association
(OVID Available online 2002)
卷期:
Volume 91,
issue 11
页码: 988-998
ISSN:0009-7330
年代: 2002
出版商: OVID
关键词: tumor necrosis factor;inflammatory mediators;clinical trial;etanercept;infliximab
数据来源: OVID
摘要:
Abstract—Recent studies have identified the importance of proinflammatory mediators in the development and progression of heart failure. The growing appreciation of the pathophysiological consequences of sustained expression of proinflammatory mediators in preclinical and clinical heart failure models culminated in a series of multicenter clinical trials that used “targeted” approaches to neutralize tumor necrosis factor in patients with moderate to advanced heart failure. However, these targeted approaches have resulted in worsening heart failure, thereby raising a number of important questions about what role, if any, proinflammatory cytokines play in the pathogenesis of heart failure. This review will summarize the tremendous growth of knowledge that has taken place in this field, with a focus on what we have learned from the negative clinical trials, as well as the potential direction of future research in this area.
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