PMR Spectrometric Analysis of Tolmetin Sodium in Capsules Forms
作者:
AbdulrahmanM. Al-obaid,
MohamedE. Mohamed,
El-RasheedA. Gad-kariem,
期刊:
Spectroscopy Letters
(Taylor Available online 1989)
卷期:
Volume 22,
issue 3
页码: 269-277
ISSN:0038-7010
年代: 1989
DOI:10.1080/00387018908053876
出版商: Taylor & Francis Group
关键词: PMR spectrometry;Pharmaceutical analysis;Assay of tolmetin sodium.
数据来源: Taylor
摘要:
An analytical method is described for the assay of tolmetin, 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid, as sodium salt, (Tolectin[rgrave] - 200 mg) using PMR. The protocol reported in this study is simple, precise and yields accurate results of 99.78±0.84 and 100.67±2.08 for the authentic material and capsules respectively. In addition, the PMR spectrum obtained provides a means for qualitative identification of the drug and checking its purity. The principle of the method involves comparison of the integral of the well-defined singlet (positioned at 2.41 Δ) to that of the sharp singlet due -CH3(positioned at 1.91 Δ) of sodium acetate as an internal standard in presence of maleic acid using DMSO-d6solvent. The rationale for the use of maleic acid in the assay procedure has been discussed.
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