Renal Potassium Handling during States of Low Aldosterone Bio-Activity: A Method to Differentiate Renal and Non-Renal Causes
作者:
Randy M. Zettle,
Michael L. West,
Robert G. Josse,
Robert M.A. Richardson,
Philip A. Marsden,
Mitchell L. Halperin,
期刊:
American Journal of Nephrology
(Karger Available online 1987)
卷期:
Volume 7,
issue 5
页码: 360-366
ISSN:0250-8095
年代: 1987
DOI:10.1159/000167502
出版商: S. Karger AG
关键词: Glucocorticoids;Hyperkalaemia;Mineralocorticoids;Urinary potassium excretion;Transtubular potassium concentration gradient
数据来源: Karger
摘要:
The purpose of this study was to examine renal potassium handling in patients with low aldosterone bio-activity. The patients with a normal renal response to aldosterone were identified by finding both a low plasma aldosterone concentration during hyperkalaemia and a transtubular potassium concentration gradient (TTKG) in the cortical distal nephron of 6 or greater within 4 h after the administration of a physiologic dose of mineralocorticoid hormone. In contrast, patients with a primary renal potassium excretion defect represent a heterogenous population. In some, the TTKG rose when a pharmacologic but not a physiologic dose of mineralocorticoid was given; others had little renal response to the administration of this hormone. Furthermore, this renal response may be delayed and require more than 24 h to become manifest.
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