Properties and Reactions of Substituted 1,2‐Thiazetidine 1,1‐Dioxides: Methylation of β‐Sultams
作者:
Martin Müller,
Hans‐Hartwig Otto,
期刊:
Archiv der Pharmazie
(WILEY Available online 1991)
卷期:
Volume 324,
issue 1
页码: 15-17
ISSN:0365-6233
年代: 1991
DOI:10.1002/ardp.19913240106
出版商: WILEY‐VCH Verlag
数据来源: WILEY
摘要:
AbstractMethylation ofN‐substituted 1,2‐thiazetidine 1,1‐dioxides in the presence of lithium diisopropylamide (LDA) yields 4,4‐dimethyl derivatives. Monomethylation only occurs when one position at C‐4 is blocked by a silyl group, which, afterwards, can be removed by treatment with tetrabutylammonium fluoride (TBAF). A silyl protecting group at the nitrogen is easily removed by cleavage with TBAF on silica gel under mild c
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