Interactions of interferon and vinblastine on experimental tumor modei melanoma B‐16in vitro
作者:
Barbara jezersek,
Sradjan Novaković,
Gregor Sersa,
Marlja Auersperg,
W Flelschmann,
期刊:
Anti-Cancer Drugs
(OVID Available online 1994)
卷期:
Volume 5,
issue 1
页码: 53-56
ISSN:0959-4973
年代: 1994
出版商: OVID
关键词: B-16 melanoma;cell culture;human recombinant IFN-α A/D;murine recombinant IFN-γ;synergy;vinblastine
数据来源: OVID
摘要:
In this study, we tried to definein vitrointeractions of two antitumor agents that have different sites and different mechanisms of action. Vinblastine (VLB) in combination with human recombinant interferon-α A/D (rHulFN-α A/D) and in combination with murine recombinant interferon-γ (rMulFN-γ) was studied. The effect of the combination was determined with cell growth kinetics assay on B-16 melanoma and the interaction defined by means of Spector's formula. Both the combination of rHulFN-α A/D with VLB and the combination of rMulFN-γ with VLB synergistically inhibited cell growthin vitro.There was a positive biochemical modulation between the two drugs, but it is still unknown whether it occurred at the level of uptake into the cell, metabolism within the cell or egress from the cell.
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