The kanban-based operation of a mixed model manufacturing line is studied. Features of the hypothetical manufacturing line modelled are presented in terms of general structure, major components and operational characteristics. Simulation model developed is described and parameters of the base model are given. Experimental design features are discussed with respect to simulation related issues, performance measures, statistical analysis and experimental design clusters. Statistical findings are summarized in tabular format. Non-intuitive behaviour observed in each experiment set is interpreted.