Utility of Diazotized 4 - Amino-6-Chloro-1,3-Benzene Disulphonamide for the Spectrophotometric Determination of 8-Hydroxquinolines and Dibenzazepines.
作者:
P.Y. Khashaba,
I.H. Refaat,
K.M. Emara,
H.M. Gaber,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 15
页码: 3029-3047
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908543025
出版商: Taylor & Francis Group
关键词: Spectrophotometry;diazotization;8-hydroxyquinolines;dibenzazipines.
数据来源: Taylor
摘要:
The present study is based on the interaction of diazotized 4-amino-6-chloro-1,3-benzene disulphonamide (DACBS) with 8-hydroxyquinolines in slightly alkaline medium and with dibenzazepines in strongly acidic medium to form red coloured products in the range of 500- 555 nm. Under optimum reaction condition, Beer's law is obeyed in the concentration range 0.5-25 μg/ml for 8-hydroxyquinolines and 1.0-25 μg/ml for dibenzazepines. The stoichiometry of the reaction was investigated and was found to be 1:1 for all the studied drugs. Interference due to other co-formulated drugs, common additives and excepients was studied. The proposed method was applied successfully for the determination of the cited drugs in their pharmaceutical preparations and results were comparable with that of the official, reported method.
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