Selective Class III Antiarrhythmic Properties of a Novel Agent, UK‐66,914, During Chronic Myocardial Infarction
作者:
JOHN R. ONUFER,
HARRIS W. DALRYMPLE,
PETER B. CORR,
期刊:
Journal of Cardiovascular Electrophysiology
(WILEY Available online 1991)
卷期:
Volume 2,
issue 2
页码: 117-133
ISSN:1045-3873
年代: 1991
DOI:10.1111/j.1540-8167.1991.tb01311.x
出版商: Blackwell Publishing Ltd
关键词: antiarrhythmic agents;potassium channels;ventricular tachycardia;conduction velocity;myocardial infarction
数据来源: WILEY
摘要:
Antiarrhythmic Properties of UK‐ 66,914.UK‐66,914 is a potent Class III antiarrhythmic agent that has no effect on conduction velocity in normal tissue in vitro. The present study was performed to evaluate the influence of UK‐66,914 on conduction velocity in vivo in canine hearts with a previous myocardial infarction. Detailed three‐dimensional mapping of the heart in vivo was obtained using simultaneous recordings from 232 transmural sites. In dogs with a chronic anterior myocardial infarction, UK‐66,914 (50μg/kg) did not alter conduction velocity in regions exhibiting normal conduction (gt; 50 cm/sec) or regions with slowed conduction (30 cm/sec, 15‐30 cm/sec, or<15 cm/sec, whereas procainamide significantly decreased conduction velocity at all three levels. Evaluation of the hemodynamic profile of UK‐66,914 revealed no negative ionotropic effects in conscious dogs even at doses twentyfold those required to elicit increases in the effective refractory period. Therefore, UK‐66,914 is a potent and specific Class III antiarrhythmic agent, which does not alter conduction velocity in hearts with a previous myocardial infarction and exer
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