Arterial and/or venous thrombosis is a frequent complication in experimental or human pancreatic transplantation. A canine experiment was used to study the hemodynamic effects of spleno-splenic arteriovenous fistula during segmental pancreatic transplantation. An increase in blood flow, without “steal” syndrome in the pancreatic blood supply or preasure increase, was found. Thus this technique can help prevent vascular thrombosis in pancreatic transplant in dogs.