On the basis of the degree of mineralization, the groundwater of Apan-Tochac sub-basin may be considered as fresh (TDS < 500 ppm). However, chlorination is necessary to make it fit for human consumption. Major ion analyses of over 235 water samples reveal a striking relationship between hydrochemical evolution and the groundwater flow system. A high content of total dissolved solids, and low values of the Ca:Mg ratio are present in wells located on the plain (discharge zone), whereas opposite conditions are associated with wells located in higher regions (recharge zone). Statistical data analysis using the method of principal components allowed to differentiation of two hydrochemical families: (a) low mineralization corresponding to the recharge zone, and (b) high mineralization corresponding to the discharge zone. Waters of the Ca + Mg + HCO3, and Na + Mg + HCO3hydrochemical fades are present and the former is dominant. The water is slightly alkaline, having slight problems of salinity during the year owing mainly to Ca2+HCO3−and Na+Cl−salts. The hydrochemistry of the groundwater reflects the pattern of local groundwater flow for this sub-basin.