A comparison of intraocular pressure elevating activity of loteprednol etabonate and dexamethasone in rabbits
作者:
BodorNicholas,
BodorNicole,
MeiWhei,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue 6
页码: 525-530
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689209001808
出版商: Taylor&Francis
数据来源: Taylor
摘要:
A“Soft”corticosteroid, loteprednol etabonate I, designed based on the“inactive metabolite”concept can be used as a safe ophthalmic anti-inflammatory drug. By design, the metabolism of I follows a predicted biotransformation pathway, thus unwanted systemic side effects are avoided. Local side effects are also reduced. Accordingly, in a cross-over study I did not elevate the intraocular pressure (IOP) in rabbits, as opposed to dexamethasone.
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