In this paper, Fisher information matrix about the five parameters ρ, μ:1, μ2, λ1and λ2of a mixture of two Inverse Gaussian density functions is obtained. The Leguerre-Gauss quadrature formula is used to evaluate the essential integral on which the twenty five elements of the information matrix are based. Results involving the computation of the information about p are compared with those involving both the power series expansion and Simpson's method of integration. Laguerre-Gauss quadra-ture was found to lead to good approximations as compared with other methods. It was therefore chosen for the computations of the elements of the information matrix.