Short‐Term Effect of Cyclosporin Injections on Experimental Gingival Inflammation in the Rat†
作者:
Joseph Hemmerle,
Robert M. Frank,
期刊:
Journal of Periodontology
(WILEY Available online 1993)
卷期:
Volume 64,
issue 1
页码: 24-28
ISSN:0022-3492
年代: 1993
DOI:10.1902/jop.1993.64.1.24
出版商: Wiley
数据来源: WILEY
摘要:
Experimental gingivitis was inducedin 2 groups of 10 adult Wistar rats by feeding them a high sucrose diet for 30 days. Since cyclosporin has an immunosuppressive effect on the stimulation of T lymphocytes, the test group received 5 intraperitoneal injections of cyclosporin A from day 20 to 30 while the control group received no additional treatment. The gingival regions of the molars were studied in light and transmission electron microscopy. In both groups, a well‐differentiated wall of polymorphonuclear neutrophils (PMNs) was present between the dental plaque and the papillary epithelium and no bacterial invasion occurred despite the local absence of T lymphocytes in the test group. It can be concluded that T lymphocytes are not involved in the mechanism of bacterial invasion.J Periodontol 1993; 64:24–28.
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