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The preparation of14C,35S and13C labelled forms of omeprazole

 

作者: A M Crowe,   R J Ife,   M B Mitchell,   D Saunders,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1986）
卷期: Volume 23, issue 1  

页码: 21-33

 

ISSN:0362-4803

 

年代: 1986

 

DOI:10.1002/jlcr.2580230104

 

出版商: John Wiley&Sons, Ltd.

 

关键词: H+/K+ATPase inhibitors;isotopically labelled carbon disulphide;omeprazole;high performance liquid chromatography;2‐[methyl‐14C]methylpyridine

 

数据来源: WILEY

 

摘要:

AbstractThe syntheses of [benzimidazole‐2‐14C]omeprazole, [benzimidazole‐2‐13C]omeprazole, [35S]omeprazole and [2‐pyridyl‐14C‐methyl]‐omeprazole are described. The first three compounds were prepared from the approprlate isotopically labelled carbon disulphide. The key step in the synthesis of [2‐pyridyl‐14C‐methyl]omeprazole is nucleophilic alkylation of a 1‐ethoxypyridinium salt using [14C]methyl magnesium idodide. This is the first time that a reaction of this type has been used to prepare a 2‐[m

 

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