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Simultaneous monitoring of the enantiomeric purities of both substrate and product in the enzymatic resolution of (R,S)‐2‐acetoxy‐3‐bromopropylpara‐toluenesulfonate by HPLC chiral column chromatography

 

作者: Grace F.S. Yin,   Y. G. Chang,   C. M. Kiang,   G. M. Chen,  

 

期刊: Chirality  （WILEY Available online 1995）
卷期: Volume 7, issue 1  

页码: 20-22

 

ISSN:0899-0042

 

年代: 1995

 

DOI:10.1002/chir.530070104

 

出版商: Alan R. Liss, Inc.

 

关键词: Chiralcel OD column;direct reaction monitoring;β‐blocker intermediate;Amano lipase AK;enantiomeric excess;timolol

 

数据来源: WILEY

 

摘要:

AbstractThe enantiomeric purities of both substrate, 2‐acetoxy‐3‐bromopropylpara‐toluenesulfonate (I), and product, 2‐hydroxy‐3‐bromopropylp‐toluenesulfonate (II) were examined in one analysis. The enzymatic resolution was conducted by Amano lipase AK and the enantiomeric excess as well as the conversion rate were monitored by HPLC analysis utilizing a Chiralcel OD column. After 7 h of reaction, HPLC results indicated that the enantiomeric purities of both substrate (I) and product (II) were greater than 95% and the conversion rate was around 55%. © 1995

 

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