Central Serotoninergic Stimulation by Fenfluramine Challenge Does Not Affect Plasma Thyrotropin-Stimulating Hormone Levels in Man
作者:
Emil F. Coccaro,
Larry J. Siever,
Ione A. Kourides,
Federico Adan,
Gordon Campbell,
Kenneth L. Davis,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 47,
issue 4
页码: 273-276
ISSN:0028-3835
年代: 1988
DOI:10.1159/000124924
出版商: S. Karger AG
关键词: 5-Hydroxytryptamine;Thyrotropin-stimulating hormone;Prolactin
数据来源: Karger
摘要:
Thyrotropin-stimulating hormone (TSH) and prolactin (PRL) responses to an acute oral challenge of fenfluramine (60 mg), a central serotoninergic (5-hydroxytryptamine) releasing/uptake inhibiting agent, were examined in 8 healthy males in order to assess the role of central serotoninergic stimulation in the release of TSH. Plasma PRL, but not TSH, was significantly elevated by fenfluramine. These data suggest that central serotoninergic activity does not play an important role in the physiologic release of plasma TSH in man. Further, thyrotropin-releasing hormone is unlikely to be the PRL-releasing factor involved in the fenfluramine-induced stimulation of PRL.
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