The Distribution of T and B Lymphocyte Populations and MHC Class II Expression in Human Fetal and Postnatal Intestine
作者:
GARY,
RUSSELL ATUL,
BHAN HARLAND,
期刊:
Pediatric Research
(OVID Available online 1990)
卷期:
Volume 27,
issue 3
页码: 239-244
ISSN:0031-3998
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
The development of the intestinal mucosal immune barrier is an important protective adaptation for postnatal life. The distribution and phenotype of T and B lymphocytes in human fetal intestine and lymphoid tissues have been characterized and compared to the distribution and phenotype of lymphocytes in postnatal intestine. The characterization of lymphocyte phenotype and MHC class II antigen distribution was done using MAb and an avidinbiotin complex immunohistochemical staining technique. Intraepithelial lymphocytes were occasionally present in fetal intestine and were primarily CD3+, CD8+. T lymphocytes were readily identified in the lamina propria of fetal intestine, but most were clustered in lymphoid aggregates. Cells identified by anti-IgA1and anti-IgA2were the most numerous cells of B cell lineage in the lamina propria of postnatal intestine, whereas IgM+and IgD+lymphocytes predominated in fetal tissues. However, IgA-bearing cells were identified in lymphoid aggregates of the intestine or spleen of some fetuses. This finding suggests that B lymphocytes can undergo Ig switchingin utero. Additionally, fetal intestinal epithelial cells did not express MHC class II antigens, unlike some postnatal intestinal tissues. It is possible that postnatal events such as antigen exposure may be important for the induction of these class II antigens on intestinal epithelial cells.
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