A Possible Role of Thromboxane A2in Endothelium in Maintaining Resting Tone and Producing Contractile Response to Acetylcholine and Arachidonic Acid in Canine Cerebral Arteries
作者:
Hiroaki Shirahase,
Motohatsu Fujiwara,
Hachiro Usui,
Kazuyoshi Kurahashi,
期刊:
Journal of Vascular Research
(Karger Available online 1987)
卷期:
Volume 24,
issue 3
页码: 117-119
ISSN:1018-1172
年代: 1987
DOI:10.1159/000158682
出版商: S. Karger AG
关键词: Endothelium;Thromboxane A2;Acetylcholine;Arachidonic acid
数据来源: Karger
摘要:
Endothelial thromboxane A2 (TXA2) in maintaining the resting tone and producing the contractile response to acetylcholine (ACh) and arachidonic acid was studied in canine cerebral artery. The spontaneous release of TXB2 from cerebral artery was about tenfold higher than that of coronary, mesenteric and saphenous arteries. The resting tone, the release of TXB2 and the contraction produced by arachidonic acid were decreased by the presence of cyclooxygenase inhibitor, TXA2 synthetase inhibitor, TXA2 antagonist and rubbing of the luminal side of preparations. The contraction produced by ACh was inhibited by the presence of the above inhibitors and rubbing of the preparations without decreasing the release of TXB2. These results suggest that the resting tone of canine cerebral artery and the contractile response to arachidonic acid are related to activation of TXA2 synthesis in the endothelium.
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