On the Nature of the Hemolytic Activity of Sendai Virus
作者:
Raffaele Caliò,
Nicoletta Caliò-Villani,
Enrico Garaci,
Giampietro Ravagnan,
Roberto Strom,
期刊:
Intervirology
(Karger Available online 1973)
卷期:
Volume 2,
issue 3
页码: 160-172
ISSN:0300-5526
年代: 1973
DOI:10.1159/000149419
出版商: S. Karger AG
关键词: Hemolytic activity;Sendai virus
数据来源: Karger
摘要:
The kinetics of the hemolysis caused in human erythrocytes by Sendai virus is strongly dependent on the virus-to-erythrocyte ratio.Two processes appear to take place: a reversible one where the virus binds to the cell membrane, causes a lesion and eventually hemolysis, and is then slowly eluted in a still active form; and an irreversible one, possibly related to fusion of the viral envelope with the erythrocyte membrane, which results in the inactivation of the virus. The extent of hemolysis depends on the relative rates of the two processes, and the final number of lysed cells is approximately proportional to the logarithm of virus concentration. The kinetics of the process is sigmoid at high virus-to-erythrocyte ratios and hyperbolic under conditions where a virus particle causes the lysis of several cells before completion of the process.
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