TECHNIQUEEndoscopic transsphenoidal surgery. New, developing, minimally invasive technique. Removal of pituitary lesions and tumors of the parasellar region.TECHNICAL DEVELOPMENTEndoscopic endonasal transsphenoidal surgery. Endonasal, not transnasal, procedure. Great respect of anatomy. Very wide surgical field, without intraoperative use of a nasal speculum, but with less room in which to work (only one nostril) and potential conflict between the surgeon’s hands and the endoscope (both when entering the nostril and while working inside).INSTRUMENTATIONNew instrument. Secure grip. Barycenter of the instrument is the surgeon’s hands. Many different tips with different functions. Elimination of the bayonet-like shape. Handle bent in the horizontal plane to avoid interference with the surgeon’s hands and to allow the distal, thin part of the instrument to be used safely and comfortably.