Hepatic Dysfunction Due to Intravenous Abuse of Methylphenidate Hydrochloride
作者:
Hershad Mehta,
Bruce Murray,
Thomas Loludice,
期刊:
Journal of Clinical Gastroenterology
(OVID Available online 1984)
卷期:
Volume 6,
issue 2
页码: 149-152
ISSN:0192-0790
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
Methylphenidate-induced hepatic injury was documented by abnormal liver function tests including a markedly elevated serum bilirubin, serum glutamic oxaloacetic transaminase, and serum glutamic pyruvic transaminase. Liver biopsy confirmed portal inflammation and hepatocellular disarray. Enzyme changes were reproducible with rechallenge of the drug (Ritalin). The drug is capable of producing hepatic injury, particularly when given in nonstandard doses intravenously.
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