The influence of vitamin C on antipyrine pharmacokinetics in elderly men
作者:
James Blanchard,
Ramanuj Achari,
Gail G. Harrison,
Kenneth A. Conrad,
期刊:
Biopharmaceutics&Drug Disposition
(WILEY Available online 1984)
卷期:
Volume 5,
issue 1
页码: 43-54
ISSN:0142-2782
年代: 1984
DOI:10.1002/bdd.2510050107
出版商: John Wiley&Sons, Ltd.
关键词: Antipyrine;Pharmacokinetics;Vitamin C;Elderly men
数据来源: WILEY
摘要:
AbstractThe influence of vitamin C on the pharmacokinetics of antipyrine was investigated in eleven elderly men aged 65–74. Antipyrine (15 mg kg−1) was administered intravenously on three separate occasions over a 7‐week period: (a) before dietary vitamin C restriction, (b) after approximately 5 weeks of dietary vitamin C restriction, and (c) after 2 weeks of vitamin C supplementation (500 mg orally twice daily). The mean plasma and leucocyte vitamin C levels (±S.D.) before vitamin C restriction were 1·26 ± 0·31 mg dl−1and 26·6 ± 6·7 μg 10−8leucocytes, respectively. These values decreased and then increased significantly following vitamin C restriction and supplementation, respectively. The mean plasma half‐life of antipyrine was 10·2h and the mean plasma clearance was 2·561h−11·73 m−2before vitamin C restriction. No significant changes in the clearance, volume of distribution, or half‐life of antipyrine occurred during the study, indicating that short‐term alterations in vitamin C intake do not affect the pharmacokinetics
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