Induction of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Granulocyte Colony-Stimulating Factor (G-CSF) Expression in Bone Marrow and Fractionated Marrow Cell Populations by Interleukin 3 (IL-3): IL-3-Mediated Positive Feedback Mechanisms of Granulopoiesis
作者:
TsujiTakashi,
SugimotoKenkichi,
YanaiTakanori,
TakashitaEmi,
MoriKazuhiro J.,
期刊:
Growth Factors
(Taylor Available online 1994)
卷期:
Volume 11,
issue 1
页码: 71-79
ISSN:0897-7194
年代: 1994
DOI:10.3109/08977199409015052
出版商: Taylor&Francis
关键词: hemopoiesis;IL-3;GM-CSF;G-CSF;IL-6;cytokine network;positive feedback mechanism
数据来源: Taylor
摘要:
AbstractInterleukin 3 (IL-3) induces proliferation and differentiation of mast cell progenitorsin vitro, whereas it induces granulocytosisin vivo. In this paper, a positive feedback mechanism of granulopoiesis was studied in order to elucidate the granulocytosis induced by IL-3 in mouse. IL-3 induced expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) in total bone marrow cells and a marrow adherent cell population. In fractionated marrow cell populations, a different expression pattern of induction by IL-3 stimulation was observed; GM-CSF was expressed in macrophages and fraction 1 (P<1.061) and 2(1.061
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